Malaria is a serious disease that’s caused by a parasite known as Plasmodium and it spread through the bite of an infected female mosquito. The parasite travels to the liver via the blood and then out into the bloodstream again, where it invades the red blood cells. There are four different types of malaria parasite: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malaria. The classical Malaria symptoms are fever and shivering. Malaria attack starts with fever, and temperature rising as high as 40C and falling again over a period of several hours.
Other Malaria Symptoms may include fatigue, nausea, severe headache, and vomiting. Malaria symptoms usually appear between 10 and 15 days after the mosquito bite. The malaria treatment is very complicated because different types of malaria require different types of drugs. Malaria treatment comes in the form of antimalarial drugs and depends upon the sternness of disease. Alaxin plus Tablets, Lonart Suppository and P-Alaxin Tablets are some medicines for malaria. Symptoms of malaria are fast controlled by Dihydroartemisinin, which is powerful plasmodicide of malaria parasite agamete.
There is no any mutuation effects experienced of it. It is widely distributed in the liver, kidneys and bile. For inhibit the enzyme dihydrofolate reductase, Pyrimethamine and sulfadoxine take steps in sequence in the bacterial path way of folic acid synthesis. That converts dihydrofolate to tetrahydrofolate. Alaxin Plus Tablets contains Sulfadoxine and pyrimethamine which do not affect mammalian cells while these mammalian cells are unable to synthesize folic acid themselves and require intact folic acid. Each Lonart Suppository contains Artemether 20 mg and Lumefantrine 120 mg. Excipients q.s. Artemether is the most active derivate of the Artemisinines, a new class of antimalarial drugs derived from Artemisinin. The latter compound is extracted from the plant Artemisia Annua and Artemether is prepared semi-synthetically. Lumefantrine is a synthetic aryl amino alcohol similar to mefloquine and halo-fantrine.
Lonart Suppository is used to treatment of malaria, which is caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. Falciparum. Each coated tablet of P-Alaxin Tablets contains Dihydroartemisinin 40 mg, Piperaquine Phosphate 320 mg, Excipients: q.s. It is used when P. falciparum, P, Vivax and P. malariae attack. This medicine is not suggested for use in women during the first 3 months of pregnancy. These tablets should keep in dry and cold places.